Kinase相关论文
24. The transcription factors and the relevant signaling pathways activated by low concentration MNN
Aims: To explore the transcription factors and related signal transduction pathways activated in the alkylating agents N......
Upconversion Fluorescence Resonance Energy Transfer for Highly Sensitive Detection of Kinase and Pho
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Loopβ3αC plays an important role in the structure and function of isocitrate dehydrogenase kinase/ph
This work aims to investigate the role of the loopβ3αC amino acids in the structure and function of isocitrate dehydro......
K63-linked TAK1 Polyubiquitination at Lys-158 Residue is Required for TNFα and IL-1 β-induced IKK/NF
TAK1 plays an easential role in proinflammatory cytokine TNFα and IL-1β-induced IKK/NF-κB and JNK/AP-1 activation.Her......
Isocitrate dehydrogenase kinase/phosphatase(AceK)is a bifunctional enzyme with both kinase and phosphatase activities th......
Systematic analysis of plant phosphoproteomes reveals that site-specific kinase-substrate networks a
Protein phosphorylation is one of the most important and essential post-translational modifications (PTMs).It plays a cr......
Kinases and GTPases,the major players in cell signaling pathways,control diverse biological processes in a precisely con......
Protein kinases and their substrates represent the largest signaling network that regulates protein-protein interactions......
背景:50%以上胶质母细胞瘤(Glioblastoma,GBM)中存在表皮生长因子受体(Epidermal growth factor receptor,EGFR)过表达或突变,但EG......
Auxin acts as a key hormone in plant that determines many developmental processes by the typical concentration dependent......
Paeoniflorin-6′-O-benzene sulfonate ameliorates progression of adjuvant-induced arthritis by inhibit
OBJECTIVE Aryl hydrocarbon receptor(Ahr)is thought to be a crucial factor that regulates immune responses,which may be i......
N2L,a novel lipoic acid-niacin dimer,attenu⁃ates ferroptosis and decreases lipid peroxida⁃tion in HT
OBJECTIVE N2L is a novel lipoic acid-niacin dimer regulating lipid metabolism with multifunction,including antioxidant e......
Tale of two kinases:Protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase II in pre-diabe
Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations,including ......
Chronic myeloid leukemia (CML) associated with pregnancy is a very rare situation (less than one case per 100</span></sp......
Allogeneic hematopoietic stem cell transplantation in a 3-year-old boy with congenital pyruvate kina
BACKGROUND The understanding regarding genetic variation,pathophysiology,and complications associated with pyruvate kina......
Detection of EGFR-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case r
BACKGROUND Gastric cancer is the fifth most diagnosed cancer worldwide and the third most common cause of cancer-related......
Sarcoidosis mimicking metastases in an echinoderm microtubuleassociated protein-like 4 anaplastic ly
BACKGROUND Rearrangements of the anaplastic lymphoma kinase(ALK)gene(ALK-positive)represent an oncogenic driver in appro......
BACKGROUND Histological transformation is one of the numerous mechanisms of acquired resistance to epidermal growth fact......
Rapidly progressing primary pulmonary lymphoma masquerading as lung infectious disease:A case report
BACKGROUND Primary anaplastic large cell lymphoma of the lung represents a diagnostic challenge due to diverse manifesta......
Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A ca
BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(......
Placenta Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia and Normotensive Pregn
Background: Preeclampsia (PE) is still one of the leading causes of maternal/perinatal morbidity/mortality in Nigeria. I......
India is no exception to the economic setback due to coronavirus disease 2019 (COVID-19). Loss of jobs and income dramat......
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adi
Beige adipocytes have been considered as a potential strategy in anti-obesity therapy because of its thermogenic capacit......
Protein kinases and their substrates comprise extensive signaling networks that regulate many diverse cellular funct......
Activity-based chemical probes (ABPs) have gained significant interests in both chemical biology and drug discovery rese......
Protein function originates from a cooperation of structural rigidity,dynamics at different timescales and allostery......
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The great abundance of cellulose places it at the forefront as a primary source of biomass for a renewable energy so......
Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tu......
Ethanolic extract of Azadirachta indica ameliorates ovarian defects through phosphoinositide-3 kinas
Objective:To assess the therapeutic potential of ethanolic extract of Azadirachta(A.)indica in rats with polycystic ovar......
Many of the effects of Ca2+ signaling are mediated through the Ca2+/calmodulin complex and its acceptors, the Ca2+/calmo......
Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser/Thr
A novel full-length cDNA encoding a putative serine/threonine kinase has been isolated from a human testis cDNA library.......
Protein kinase B (PKB) is a member of the second messenger-regulated subfamily of protein kinases, and plays a key role ......
To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect ......
Induction of matrix metalloproteinase-9 and-2 activity in mouse blastocyst by fibronectin-integrin i
Fibronectin, a major extracellular matrix, plays an important role in embryo implantation by mediating embryo adhesion a......
The kinetic theory of the substrate reaction during the modification of enzyme activity previously described by Tsou has......
The cyanolysis of DTNB-modified creatine kinase(S,S’-di-TNB-CK)has been studied.Itwas found that there exist both cyano......
Six hybridoma cell lines that can continuously secrete monoclonal antibodies against adenylate kinase (AK) have been pro......
Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects,including cell growth,differentiat......
Study of Mutation in Tyrosine Protein Kinase of Insulin Receptor Gene in Patients with Polycystic Ov
Objective To explore the molecular mechanism of insulin resistance in the patients with polycystic ovarian syndrome (PC......
Effects of Total Flavonoids in Drynaria fortunei (Kunze)J. Sm. on Osteoblasts Differentiation and Ex
[Objective] To observe the effects of total flavonoids in Drynaria fortunei (Kunze) J. Sm. (TFDF) on osteoblasts (OB) di......
Changes of Protein Kinase Cα and Cyclin D1 Expressions in Pulmonary Arteries from Smokers with and w
The purpose of this study was to investigate the changes of protein kinase Cα(PKCα) and cyclin D1 expressions in pulmo......
研究铅及蛋白激酶C的激活剂在收缩过程中对钙信号系统的影响。制各家兔肠系膜动脉血管条，悬吊于浴槽中．其张力变化经换能并放大后描......
Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of can......
Effect of Metformin on Tyrosine Kinase Autophosphorylation of Erythrocyte Insulin Receptor from Wome
Objective To document the possible effect of tyrosine kinase autophosphorylation on erythrocyte insulin-receptor after 1......
Vascular insulin resistance in prehypertensive rats contributes to the development of hypertension:R
Objective: It is well known that systemic insulin resistance (IR) is closely associated with the metabolic syndrome incl......
ROCK也称Rho相关激酶(Rho-Associated Kinase),简称Rho激酶(Rho Kinase),作为一种丝氨酸/苏氨酸蛋白激酶,是小G蛋白(Small G Prote......
动脉粥样硬化(Atherosclerosis,AS)是心脑血管疾病的重要病理生理基础,近年来,大量人体和动物实验研究表明,5-脂氧合酶(5-Lipoxyge......
Jailing polymer jacketed guide-wires during bifurcation coronary interventions is associated with pr
AIM To study the relationship of jailed polymer jacketed guide wires(PGW) with procedural myocardial infarction(PMI) aft......
